Study of effectiveness of FIR and IIR filters in Exon identification: A comparative approach

Abstract

In recent years, DSP has been widely used in the area of DNA sequence analysis, detection of protein cod-ing and non-coding regions and also in finding abnormalities present in coding and non-coding regions. Using DSP tool, the detection of protein coding and non-coding regions has been executed with great accuracy and less complexity. In this paper, DNA nucleotide sequence is converted into corresponding EIIP sequence in the first step. In order to make a comparative study between different FIR and IIR filters, the sequence is passed through overall six FIR and IIR filters separately to extract the period three fre-quency components. Finally, Gaussian filter is used to suppress the high frequency noise present in the power spectrum. This study aims to find out most efficient FIR and IIR filters in predicting exons (coding regions) and introns (non-coding regions) based on different evaluating parameters as follows: (i) specificity-sensitivity values (ii) Matthews correlation coefficient (iii) Miss rate and wrong rate (iv)Discriminating factor (v) ROC.